Fig. 3. Maximum likelihood analyses of the ECE family of proteins following the WAG model of amino acid substitutions (Whelan and Goldman, 2001), and a gamma distribution of 1.03. There are three distinct groups of ECE: ECE1, ECE2 and non-vertebrate ECE. Accession numbers: Archaea ECE, NP_616924; Bacteria ECE, NP_812722; chicken ECE1, NP_990048; chicken ECE2, ENSGALP00000010123; frog ECE1, AAH46653; frog ECE2, ENSXETP00000037627; fungus ECE, XP_754379; human ECE1, NP_001388; human ECE2, NP_055508; hydra ECE, AAD46624; killifish ECE1, EU009476; lancelet ECE, 86342 scaffold_150000101; locust ECE, AAN73018; medaka ECE2, ENSORLP00000025753; medaka ECE1, ENSORLP00000021332; mouse ECE1, NP_955011; mouse ECE2, NP_647454; opossum ECE1, ENSMODP00000019967; opossum ECE2, ENSMODP00000002887; platypus ECE1, ENSOANP00000023244; platypus ECE2, ENSOANP00000003016; rat ECE1, NP_446048; rat ECE2, NP_001002815; sea squirt ECE, ENSCSAVP00000016300; sea urchin ECE, XP_798822; stickleback ECE1, ENSGACP00000006069; stickleback ECE2, ENSGACP00000005922; Takifugu ECE1, NEWSINFRUP00000136873; Takifugu ECE2, NEWSINFRUP00000151424; Tetraodon ECE1, GSTENP00006535001; Tetraodon ECE2, CAG02177; zebrafish ECE1, XP_694687. Scale bar represents the number of replacements per site.