Fig. 6. Specific drugs have differential agonist activity at 5-HT_2β and 5-HT₁. (A) Release of IP in cells expressing 5-HT_2βPro (right) in response to various putative agonist drugs (10^–3 mol l^–1, except methysergide, 10^–5 mol l^–1). Non-transfected HEK cells (left) show no IP release in response to the drugs. Values are means ± s.e.m., N=3, ^***P<0.001 and ^*P<0.05 vs no drug. (B) Inhibition of forskolin-stimulated cAMP production in response to the same drugs in cells induced to express 5-HT_1Pro. Values are means ± s.e.m., N=3, ^#P<0.05 vs non-induced, ^**P<0.001 and P<0.05 vs forskolin only.