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Journal of Experimental Biology 11,262-266 (1934)
Published by Company of Biologists 1934

Regression of Anterior Pituitary Reactions II and III in the Mouse Ovary

WALTER P. KENNEDY ¹

¹ Department of Physiology, Edinburgh University

The effects on the ovary of an amount of prolan just sufficient to produce 100 per cent. reaction in infantile mice may persist up to at least 60 days after administration. Blood points may be visible after 35 days. Many of the ovaries remained in the infantile state. It is suggested that this long duration effect may be explained by the reciprocal influence of the prematurely stimulated gonad on the pituitary.

A small number of adult mice similarly treated (16) showed relative sterility in comparison with a control group. They also exhibited some ovarian changes. Five to eight mouse units is probably about the minimal sterilising dose for mature animals.

Part of the expenses of this investigation were defrayed by a grant from the Earl of Moray Fund; Bayer Products kindly supplied the prolan used.