QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Siegelbaum, S. Articles by Shuster, M. Search for Related Content PubMed Articles by Siegelbaum, S. Articles by Shuster, M.

Journal of Experimental Biology, Vol 124, Issue 1 287-306, Copyright © 1986 by Company of Biologists

JOURNAL ARTICLES

Modulation of the serotonin-sensitive potassium channel in Aplysia sensory neurone cell body and growth cone

SA Siegelbaum, F Belardetti, JS Camardo and MJ Shuster

Using single-channel recording, we have been able to obtain some insight into the molecular mechanism of a modulatory transmitter action in Aplysia sensory neurones. Our results show that serotonin produces a slow EPSP and increases action potential duration in the sensory neurones by producing prolonged closures of the S potassium channel. Such closures appear to be mediated by cyclic AMP-dependent phosphorylation of a membrane protein which may be the channel. Modulation of S channels by serotonin also occurs in sensory neurone growth cones. This provides the first direct evidence that channel modulation occurs in nerve processes and increases the likelihood of channel modulation at the nerve terminal.

This article has been cited by other articles:

				D. A. Baxter, C. C. Canavier, J. W. Clark Jr., and J. H. Byrne Computational Model of the Serotonergic Modulation of Sensory Neurons in Aplysia J Neurophysiol, December 1, 1999; 82(6): 2914 - 2935. [Abstract] [Full Text] [PDF]