QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by WADDINGTON, C. H. Search for Related Content PubMed Articles by WADDINGTON, C. H.

Journal of Experimental Biology 15,377-381 (1938)
Published by Company of Biologists 1938

Regulation of Amphibian Gastrulae with Added Ectoderm

C. H. WADDINGTON ¹

¹ Sub-Department of Experimental Zoology, Cambridge

1. If a young gastrula of Discoglossus pictus is cut in half along the frontal plane the dorsal half develops into the anterior part of an embryo of normal size, there being no regulation; this is probably dependent on the failure of the wound to heal. The ventral half develops as a "Bauchstuck" of the usual kind, containing endoderm, mesenchyme, with occasionally some somitic mesoderm, enclosed in a bag of ectoderm.

2. Gastrulae were cut in half along the frontal plane, and the greater part of a second gastrula, from which the dorsal and ventral regions had been removed, was inserted in the plane of the cut (Fig. 1). Complete regulation occurred in many cases, leading to the production of abnormally large embryos. In most cases, some regulation occurred, but some ectoderm was left in excess and formed an excrescence near the anus.

3. The extent of the invagination of mesoderm is determined by an interaction between the presumptive mesoderm and presumptive ectoderm.

Note:

Part of the expenses of this investigation were defrayed by a grant from the Rockefeller Foundation, for which I should like to express my gratitude.