spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McKean, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McKean, T. A.

Journal of Experimental Biology, Vol 157, Issue 1 133-142, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Calcium uptake by mitochondria isolated from muskrat and guinea pig hearts

TA McKean
Department of Biological Sciences and WAMI Medical Program, University of Idaho, Moscow, ID, USA.

Subsarcolemmal and interfibrillar mitochondria were isolated from the hearts of the diving muskrat and non-diving guinea pig and direct and indirect measurements of calcium uptake were examined in vitro. The calcium-stimulated respiration rate and 45Ca uptake were measured and found to be greater in muskrat than in guinea pig mitochondria. Muskrat mitochondria were able to endure a greater external calcium concentration than guinea pig mitochondria before exhibiting indications of inner membrane damage. Calcium uptake by muskrat heart mitochondria was inhibited more by 1 mmoll-1 MgCl2 than was uptake by guinea pig mitochondria. No differences were detected between the interfibrillar and subsarcolemmal populations of mitochondria within species. An increased ability to sequester calcium by mitochondria without causing them damage may aid an animal during recovery from hypoxia, ischemia or acidosis.


This article has been cited by other articles:


Home page
 JCBHome page
A. V. Kuznetsov, O. Mayboroda, D. Kunz, K. Winkler, W. Schubert, and W. S. Kunz
Functional Imaging of Mitochondria in Saponin-permeabilized Mice Muscle Fibers
J. Cell Biol., March 9, 1998; 140(5): 1091 - 1099.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1991