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Journal of Experimental Biology 16,143-149 (1939)
Published by Company of Biologists 1939

A Quantitative Study of Amphibian Neural Tube Induction With a Water-Soluble Hydrocarbon

S. C. SHEN ¹

¹ Zoological and Strangeways Laboratories, Cambridge

1. The water-soluble carcinogenic hydrocarbon, 1 : 2 : 5 : 6-dibenzanthracene---endo-succinate, has been implanted in carefully graded doses into gastrulae of Triton alpestris.

2. An optimal dose for neural tube formation was found at 0.0125 per embryo, and for palisade inductions at 0.000125 per embryo.

3. It is suggested that the action of this hydrocarbon at least is direct, imitating the action of the naturally occurring organizer substance, and not indirect, by injuring the ventral ectoderm so as to liberate the masked organizer substance which it contains. The effective range of dosage resembles that of many biologically active substances.

4. A parallelism exists between the frequency and the size of the neural tube inductions.

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