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Journal of Experimental Biology, Vol 200, Issue 22 2907-2912, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Fatigue of mouse soleus muscle, using the work loop technique

GN Askew, IS Young and JD Altringham
Department of Biology, University of Leeds, UK.

The function of many muscles requires that they perform work. Fatigue of mouse soleus muscle was studied in vitro by subjecting it to repeated work loop cycles. Fatigue resulted in a reduction in force, a slowing of relaxation and in changes in the force-velocity properties of the muscle (indicated by changes in work loop shape). These effects interacted to reduce the positive work and to increase the negative work performed by the muscle, producing a decline in net work. Power output was sustained for longer and more cumulative work was performed with decreasing cycle frequency. However, absolute power output was highest at 5 Hz (the cycle frequency for maximum power output) until power fell below 20% of peak power. As cycle frequency increased, slowing of relaxation had greater effects in reducing the positive work and increasing the negative work performed by the muscle, compared with lower cycle frequencies.


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© The Company of Biologists Ltd 1997