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Journal of Experimental Biology, Vol 203, Issue 12 1777-1782, Copyright © 2000 by Company of Biologists


JOURNAL ARTICLES

Cops and robbers: putative evolution of copper oxygen-binding proteins

H Decker and N Terwilliger
Institute for Molecular Biophysics, University of Mainz, Germany. decker@biophysik.biologie.uni-mainz.de.

Two closely related copper proteins, phenoloxidase and haemocyanin, are known to be involved in different physiological functions such as the primary immune response and oxygen transport. Although the proteins differ structurally, they have the same active site by which dioxygen is bound. Recent results reveal that haemocyanin also exhibits phenoloxidase activity. A scenario is proposed for the evolutionary relationships among copper oxygen-binding proteins (COPs).





© The Company of Biologists Ltd 2000