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Journal of Experimental Biology, Vol 203, Issue 6 995-1001, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Lack of effect of ageing on acetate oxidation in rat skeletal muscle during starvation: a (13)C NMR study

V Mezzarobba, G Bielicki, FM Jeffrey, M Mignon, JP Renou, J Grizard and D Meynial-Denis
Centre de Recherche en Nutrition Humaine de Clermont-Ferrand and Institut National de la Recherche Agronomique, Unite d'Etude du Metabolisme Azote, France.

Acetate oxidation was examined by (13)C nuclear magnetic resonance in skeletal muscle from adult and old rats. Rats fasted for 5 days were perfused with [2-(13)C]acetate over 2 h, and muscle extracts were analyzed for [(13)C]glutamate isotopomers. This study shows that approximately 80 % of acetyl-coenzyme A entering the tricarboxylic cycle was derived from substrate infusion in both adult and old rats, and that the flux through anaplerotic pathways was approximately 21 % of the flux through citrate synthase. These data demonstrate that skeletal muscle from adult and old rats oxidizes the same proportion of exogenous acetate.


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