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Journal of Experimental Biology 29,192-195 (1952)
Published by Company of Biologists 1952

Pharmacological Investigation of the Nature of the Innervation of the Muscles of Helix Aspersa

JAS D. P. GRAHAM 1 and R. ST A. HEATHCOTE 1

1 Department of Pharmacology, Welsh National School of Medicine, Cardiff

The isolated columellar muscle of Helix aspersa is caused to contract by addition to it of ephedrine, adrenaline, veratrine, Ba++ and acetylcholine.

Adrenaline and acetylcholine are active in concentrations of 10-6 or less.

The action of acetylcholine is potentiated by eserine and abolished by atropine, but not by curare, indicating a muscarinic cholinergic innervation of this muscle.

The heart muscle is sensitive to sympathornimetic substances only.

The muscle of the alimentary canal is insensitive to drugs.

Submitted on July 30, 1951






© The Company of Biologists Ltd 1952