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Journal of Experimental Biology 61,629-637 (1974)
Published by Company of Biologists 1974

Effects of Acetylcholine on Resting and Action Potentials, and on Contractile Force in the Ventricle Of Dolabella Auricularia

ROBERT B. HILL ¹

¹ Department of Zoology, University of Rhode Island, Kingston, Rhode Island 02881, U.S.A. and Kewalo Marine Laboratory, Pacific Biomedical Research Center, University of Hawaii, 41 Ahui St., Honolulu, Hawaii 96813, U.S.A.

Acetylcholine (2x10^-8 to 2x10^-3 M depolarized the isolated ventricle of Dolabella auricularia. The depolarization was accompanied by a negatively inotropic effect from 2x10^-8 M to 2x10^-4 M, and by a positively tonotropic effect from 2x10^-4 M to 2x10^-3 M. The interaction of acetylcholine and 5-hydroxytryptamine was studied by artificially prolonging the plateau of the cardiac action potential by treatment with 5-HT. Acetylcholine had the effect of shortening the plateau established by 5-hydroxytryptamine. Force was reduced correspondingly.

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