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Evidence for facilitated lactate uptake in lizard skeletal muscle

E. R. Donovan^* and T. T. Gleeson

Section of Integrative Physiology and Neurobiology, E.P.O. Biology, University of Colorado – Boulder, Boulder, CO 80309-0334, USA

View larger version (9K): [in a new window]   Fig. 1. Mean rate of lactate uptake by mouse soleus muscle during 1–15 min incubations. Values are means ± S.E.M., N=3–5, except at 10 min where N=2. At some points error bars are smaller than the symbols.

View larger version (10K): [in a new window]   Fig. 2. Mean rate of lactate uptake by Dipsosaurus dorsalis red iliofibularis (rIF) () and white iliofibularis (wIF) () during 1–15 min incubations. Values are means ± S.E.M., N=3–4 for rIF and wIF at each incubation time, except at 15 min where N=2. At some points error bars are smaller than the symbols.

View larger version (11K): [in a new window]   Fig. 3. Mean rate of lactate uptake for Dipsosaurus dorsalis red iliofibularis (rIF) () and white iliofibularis (wIF) () during 2 min incubations with 5 mmol l–1 intracellular and 5–100 mmol l–1 extracellular lactate. The lines are the diffusion-corrected uptake rates for rIF (dashed line) and wIF (solid line). Values are means ± S.E.M., N=4–6 for rIF and N=6–10 for wIF. At some points error bars are smaller than the symbols.

View larger version (16K): [in a new window]   Fig. 4. Rates of lactate uptake in (A) a 5 mmol l–1 intracellular:15 mmol l–1 extracellular lactate concentration gradient and (B) a 5 mmol l–1 intracellular:5 mmol l–1 extracellular concentration gradient in the presence of the monocarboxylate transporter inhibitors N-ethymaleimide (ETH) and -cyano-4-hydroxycinnamate (CIN). Values are means ± S.E.M. for red iliofibularis (rIF) (hatched columns) and white iliofibularis (wIF) (open columns); N=4–8 in A and N=3–6 in B for each fiber type in each incubation condition. Comparisons were made only within [lactate] conditions and within fiber types. Columns with different superscripts were significantly different (P0.05) for statistical comparisons made between inhibitor conditions, within a muscle type. CON, control.