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Intracardiac flow separation in an in situ perfused heart from Burmese python Python molurus

Tobias Wang1,*, Jordi Altimiras2 and Michael Axelsson2

1 Department of Zoophysiology, University of Aarhus, 8000 Aarhus C, Denmark
2 Department of Zoophysiology, University of Gothenburg, Sweden



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Fig. 1. Effects of increasing input pressure PLAt and PRAt (Frank—Starling effect) to the left atrium (LAt: A,B) or right atrium (RAt; C,D) on central flow rates (A,C) and power output (B,D) in Python molurus heart. In each of the two cases, input pressure to the other atrium was maintained constant. All values are means ± S.E.M. (N=7); an asterisk indicates significant differences (P<0.05) between systemic or pulmonary flow rates and power outputs at a given input pressure. NS, not significantly different; sys, systemic; pul, pulmonary; tot, total.

 


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Fig. 2. Effects of increasing output pressure (power curves) of the systemic (A,B) or pulmonary (C,D) outflows on central flows (A,C) and power output (B,D) of the in situ perfused Python molurus heart. In each case, output pressure of the other circulatory system was maintained at a constant level. All values are means ± S.E.M. (N=7); an asterisk indicates significant differences (P<0.05) between systemic or pulmonary flows and power outputs at a given outflow pressure. NS, not significantly different; sys, systemic; pul, pulmonary; tot, total.

 


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Fig. 3. Effects of independently changing outflow resistances in the pulmonary and systemic circulations on flow distributions before and after clamping the inflow to the right atrium (RAt; A). (B) The left bar in each panel shows the flow distribution during filling of both atria, whereas the right bars show the distribution when right atrial flow was completely abolished. The starting condition is marked by a thicker border; black bars, pulmonary vein; white bars, systemic vein. All values are means ± S.E.M. (N=7); an asterisk indicates a significant effect (P<0.05) from clamping atrial inflow. LAt, left atrium.

 


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Fig. 4. Effects of independently changing outflow resistances in the pulmonary and systemic circulations on flow distributions before and after clamping the pulmonary vein (left atrial inflow) (LAt; A). (B) The left bar in each panel shows the flow distribution during filling of both atria, whereas the right bars show the distribution when right atrial flow was completely abolished. The starting condition is marked by a thicker border; black bars, pulmonary vein; white bars, systemic vein. All values are means ± S.E.M. (N=7); an asterisk indicates a significant effect (P<0.05) from clamping atrial inflow.

 





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