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Discrete electrolytic lesion of the preoptic area prevents LPS-induced behavioral fever in toads

Kenia C. Bicego and Luiz G. S. Branco^*

Department of Physiology, Dental School of Ribeirao Preto and Department of Physiology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

View larger version (39K): [in a new window]   Fig. 1. (A) Dorsal view of the anuran brain. The level of the two coronal sections (1, 2) on the right is shown by the two solid vertical lines (adapted from Donkelaar, 1998). (B,C) Electrolytic lesions (dark areas) placed in the preoptic area (POa) of (B) seven lipopolysaccharide (LPS)-treated and (C) five saline-treated toads. Abbreviations: ca, anterior commissure; cho, optic chiasm; T, toad; vt, third ventricle.

View larger version (22K): [in a new window]   Fig. 2. Change in preferred body temperature (Tb) over time of control, sham-operated and preoptic area (POA)-lesioned toads during a period of 24 h. Values are means ± S.E.M. Numbers in parentheses indicate the number of animals.

View larger version (28K): [in a new window]   Fig. 3. Change in preferred body temperature (Tb) over time of control, sham-operated and preoptic area (POA)-lesioned toads injected into the lymph sac at time zero with either (A) pyrogen-free saline or (B) lipopolysaccharide (LPS) at a dose of 200 µg kg-1 body mass. A non POA-lesioned group injected with LPS is also plotted. Arrows indicate the time of injection. Values are means ± S.E.M. The asterisk indicates significant difference (P<0.05) from the control group at the same time points. Numbers in parentheses indicate the number of animals.