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Differing mechanisms of cold-induced changes in capillary supply in m. tibialis anterior of rats and hamsters

Durmus Deveci^1,2 and Stuart Egginton^2,*

¹ Department of Physiology, Cumhuriyet University, 58140 Sivas, Turkey and
² Angiogenesis Research Group, Department of Physiology, University of Birmingham Medical School, Birmingham B15 2TT, UK

View larger version (141K): [in a new window]   Fig. 1. A representative photomicrograph of ATPase staining from the tibialis anterior core region of a control rat; 10 µm cryostat section. The characterisation of fibre types on the basis of staining intensity is illustrated for Type I, IIa and IIb fibres. Scale bar, 100 µm.

View larger version (22K): [in a new window]   Fig. 2. Schematic cross section of tibialis anterior muscle. The numbers in squares show the relative position of the fields counted. In the cortex, fibre size is large and fibres are mainly glycolytic, whereas in the core region fibre size is smaller and fibres are more oxidative. FCSA, fibre cross-sectional area.

View larger version (25K): [in a new window]   Fig. 3. (A) Rat tibialis anterior (TA) regional fibre type distribution and mean fibre cross-sectional area (FCSA) in euthermic (open columns) and cold-acclimated (filled columns) groups. (B) Regional fibre type distribution and FCSA in hamster TA of euthermic (open columns) and cold-acclimated (filled columns) groups. N=6 animals per group. *P<0.05, **P<0.01, ***P<0.001 compared with the corresponding euthermic group. Values are means + S.E.M.

View larger version (152K): [in a new window]   Fig. 4. Photomicrographs showing alkaline phosphatase (A,B,E,F) and succinate dehydrogenase (C,D,G,H) staining from tibialis anterior cortex of euthermic (left-hand column) and cold-acclimated (right-hand column) rat (A–D) and hamster (E–H). Scale bar, 100 µm.

View larger version (26K): [in a new window]   Fig. 5. (A) Rat tibialis anterior (TA) regional differences in capillary-to-fibre ratio (C:F), capillary density (CD) and mean fibre cross-sectional area (FCSA) in core and cortex regions of euthermic (open columns) and cold-acclimated (filled columns) groups. (B) Regional differences in C:F, CD and FCSA in core and cortex regions of euthermic and cold-acclimated hamster TA. N=6 animals per group. *P<0.05, **P<0.01, ***P<0.001 compared with the corresponding euthermic group. Values are means + S.E.M.

View larger version (23K): [in a new window]   Fig. 6. Estimated regional diffusion distance in tibialis anterior (TA) muscle of euthermic and cold-acclimated rats and hamsters. 500/CD, diffusion distance (see Rakusan and Poupa, 1963); Rmax, maximum diffusion distance; Rave, average diffusion distance (see Snyder, 1987). N=6 animals per group. Values are means + S.E.M.