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The caveolar nitric oxide synthase/arginine regeneration system for NO production in endothelial cells

Larry P. Solomonson^*, Brenda R. Flam, Laura C. Pendleton, Bonnie L. Goodwin and Duane C. Eichler

Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, FL 33612, USA

View larger version (15K): [in a new window]   Fig. 1. Metabolic roles and fates of arginine. In addition to incorporation into protein, arginine serves as a metabolic precursor for several important metabolites, as indicated by the arrows. Also indicated is the two-step conversion of citrulline to arginine.

View larger version (9K): [in a new window]   Fig. 2. Novel 5' untranslated regions (UTRs) of endothelial argininosuccinate synthase mRNA.

View larger version (34K): [in a new window]   Fig. 3. Model for the coupling of endothelial NO production to the regeneration of the substrate, arginine, from the product, citrulline. Shown is the CAT1 transporter involved in arginine transport and the complex of argininosuccinate synthase and argininosuccinate lyase with endothelial nitric oxide synthase.