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First published online December 14, 2006
Journal of Experimental Biology 210, 65-74 (2007)
Published by The Company of Biologists 2007
doi: 10.1242/jeb.02625
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Associations between basal metabolic rate and reproductive performance in C57BL/6J mice

Sarah L. Johnston1,*, Donna M. Souter1, Susan S. Erwin1, Bert J. Tolkamp2, Jonathan M. Yearsley3, Iain J. Gordon4, Andrew W. Illius5, Ilias Kyriazakis2 and John R. Speakman1,6,{dagger}

1 Division of Obesity and Metabolic Health, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
2 Animal Nutrition and Health Department, Scottish Agricultural College, Kings Buildings, West Mains Road, Edinburgh EH9 3JG, UK
3 Macaulay Institute, Craigiebuckler, Aberdeen AB15 8QH, UK
4 Sustainable Ecosystems, CSIRO - Davies Laboratory, PMB PO Aitkenvale, QLD 4814, Australia
5 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
6 Aberdeen Centre for Energy Regulation and Obesity (ACERO), School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK


Figure 1
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  		Fig. 1. Scatter plot of basal metabolic rate (BMR) and body mass (Mb) of female C57BL6/J mice during a 30-day measurement period starting 10 days after weaning. The trend-line (y=0.0054x+0.0639) is for females that successfully gave birth to pups (N=265, r2=6.9%, P<0.001). There was no association between BMR and Mb for unsuccessful females (N=39; r2=0.3%, P=0.748).

 

Figure 2
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  		Fig. 2. Histogram showing the number of C57BL/6J mice that gave birth and weaned a given number of pups.

 

Figure 3
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  		Fig. 3. Scatter plots showing the relationship between the number of pups born in a litter and (A) litter mass and (B) mean pup mass per litter, which was calculated from litter mass and pup number.

 

Figure 4
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  		Fig. 4. The percentage of C57BL/6J mice that gave birth to live litters (N=304) and successfully weaned pups (N=265) in each centile of basal metabolic rate (BMR) values or residual BMR corrected for body mass (Mb). There was no significant association between the probability of birth success and either BMR (A; binary logistic regression, P=0.129) or BMR corrected for Mb (B; P=0.754), or weaning success and BMR (C; P=0.954) or BMR corrected for Mb (D; P=0.373).

 

Figure 5
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  		Fig. 5. Scatter plots of litter mass at birth against (A) body mass (Mb) (y=0.414x+2.41), (B) basal metabolic rate (BMR) (y=-0.75x+12.6) and (C) BMR corrected for Mb (y=-4.75x+12.4) for C57BL/6J mice (N=265).

 

Figure 6
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  		Fig. 6. Scatter plots of litter size at birth against (A) body mass (Mb) (y=0.48x-5.26), (B) basal metabolic rate (BMR) (y=7.2x+4.96) and (C) BMR corrected for Mb (y=3.11x+6.36) for C57BL/6J mice (N=265).

 

Figure 7
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  		Fig. 7. Scatter plots of litter mass at weaning against (A) body mass (Mb) (y=3.9x-40.6), (B) basal metabolic rate (BMR) (y=63.8x+41.7) and (C) BMR corrected for Mb (y=32.4x+54.0) for C57BL/6J mice (N=256).

 

Figure 8
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  		Fig. 8. Scatter plots of litter size at weaning against (A) body mass (Mb) (y=0.571x-7.74), (B) basal metabolic rate (BMR) (y=7.84x+4.79) and (C) BMR corrected for Mb (y=4.24x+6.31) for C57BL/6J mice (N=256).

 

Figure 9
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  		Fig. 9. The percentage of C57BL/6J mice (N=278) that were identified, by changes in body mass (Mb) following pairing with a proven breeder male, to have lost some or all pups by absorption or miscarriage in each centile of basal metabolic rate (BMR) or residual BMR corrected for Mb. Pup loss was associated with BMR (A; binary logistic regression, P<0.05) and BMR corrected for Mb (B; P=0.05).

 

Figure 10
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  		Fig. 10. The ratio of female to male pups at weaning against (A) body mass (Mb) (y=-0.0319x+0.668), (B) basal metabolic rate (BMR) (y=1.49x-0.412) and (C) BMR corrected for Mb (y=1.56x-0.099) for C57BL/6J mice (N=164).

 




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