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Figure 2


Fig. 2. The effects of the NO donor SNAP on skin cell electrophysiology. (A) Sequential measurements from a patch recording of a single skin cell, which was maintained throughout the experiment. SNAP (horizontal line) reversibly increases the impulse duration (Ai) and the delay from stimulus (Aii, but note that there is an initial decrease in delay; down arrow) and decreases the resting membrane potential (Aiii). Control (pre-application) data are shown as blue diamonds, SNAP data are magenta squares, and wash data are green triangles. (B) Individual responses to stimuli applied at times indicated by the up arrows above the time axis in (A). The resting membrane potential is shown at the start of each record. The records are aligned at the time of the stimulus, and the vertical broken line indicates the response delay in control conditions. Times to peak of skin impulses were 11.3 ms in control (Bi), 13.6 ms in SNAP (Bii) and 12.6 ms in wash (Biii).





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