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Figure 1


Fig. 1. Peptides known to reduce primary urine production [Tenmo-ADFa (ADFa), Tenmo-ADFb (ADFb) and Manse-CAP2b (CAP2b)] were tested at 1 µmol l–1 for an effect on cricket tubules, along with their second messenger cyclic GMP [1 mmol l–1 8-bromo cyclic GMP (cGMP)]. The cricket kinin Achdo-KII (1 nmol l–1; AKII) was included in the assay as a positive control. Bars represent mean values for the change in rate of secretion ({Delta} pl mm–1 min–1) following addition of test compounds, and vertical lines represent + 1 s.e.m. for the number of replicates indicated in parentheses. Tenmo-ADFb and 8-bromo cyclic GMP significantly increased (***P<0.001) fluid secretion, and the response to the former was comparable to that of Achdo-KII.





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