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Fig. 7. (A) Evidence of synergism between 10 µmol l–1 8-bromo
cyclic AMP (cAMP) and 0.3 µmol l–1 Tenmo-ADFb (ADFb). Bars
represent the means + 1 s.e.m. for the change in rate of secretion (
pl
mm–1 min–1) following addition of the
secretagogues individually and together. The number of replicates is shown in
parentheses, and identical letters indicate values that differ significantly
(P<0.001). The sum of the separate responses to 8-bromo cyclic AMP
and Tenmo-ADFb (Sum) is significantly less than when they are tested together
(Both). (B) 8-bromo cyclic GMP (1 mmol l–1) increases
secretion by tubules that have been maximally stimulated by Tenmo-ADFb (10
µmol l–1) and Achdo-KII (1 nmol l–1;
AKII). Bars represent the means + 1 s.e.m. for the change in rate of secretion
( pl mm–1 min–1) after addition of
the peptides alone (open bars) and then together with 8-bromo cyclic GMP (grey
bars). Black bars show the diuretic activity of 1 mmol l–1
8-bromo cyclic GMP alone measured in separate groups of tubules. The number of
replicates is shown in parentheses, and identical letters indicate values that
differ significantly (P<0.001).
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