|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 1. Upper tubules were initially stimulated with 25 nmol l–1
5-hydroxytryptamine (5HT) in saline and fluid was collected at 10 min
intervals for a total of 20 min. The tubules then received 1 µmol
l–1 of either 5HT (filled squares) or ZooneDH (filled
triangles) and fluid was collected for a further 55 min at 5 min intervals.
The rate of fluid secretion (A) was calculated after measuring the diameter of
each droplet, and ion-selective microelectrodes were used to measure the
K+ (B), Na+ (C) and Cl– (D)
concentration of each droplet of secreted fluid. ZooneDH and 5HT stimulate
fluid secretion to a similar extent and both increase the Na+
concentration of the secreted fluid at the expense of K+ over time.
Each point is the mean ± s.e.m. of 6–9 individual tubules.
|
