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Figure 6


Fig. 6. Specific drugs have differential agonist activity at 5-HT2β and 5-HT1{alpha}. (A) Release of IP in cells expressing 5-HT2βPro (right) in response to various putative agonist drugs (10–3 mol l–1, except methysergide, 10–5 mol l–1). Non-transfected HEK cells (left) show no IP release in response to the drugs. Values are means ± s.e.m., N=3, ***P<0.001 and *P<0.05 vs no drug. (B) Inhibition of forskolin-stimulated cAMP production in response to the same drugs in cells induced to express 5-HT1{alpha}Pro. Values are means ± s.e.m., N=3, #P<0.05 vs non-induced, **P<0.001 and {dagger}P<0.05 vs forskolin only.





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