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Figure 7


Fig. 7. Example dose–response curves for agonists and antagonists at 5-HT2βPro and 5-HT1{alpha}Pro. (A) Cells expressing 5-HT2βPro respond with a dose-dependent increase in IP levels in response to 5-HT (10–3 mol l–1; black squares) and two agonists with different potencies and efficacies, 2-methyl-5-HT (black circles) and 5-XT (black triangles). The 5-HT-indexed IP response is blocked by increasing concentrations of two antagonists, methiothepin (grey inverted triangles) and cinanserin (grey diamonds). Values are means ± s.e.m., N=3. (B) Dose-dependent responses to 5-HT (squares) and two agonists, mCPP (circles) and methysergide (triangles) with different potencies and efficacies in cells induced to express 5-HT1aPro. Values are means ± s.e.m., N=3.





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