spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 8


Fig. 8. Identification of antagonists of 5-HT2β and 5-HT1{alpha}. (A) Putative antagonists have no effect on the parental HEK cell line (left). Several of the antagonists (10–5 mol l–1) block 5-HT (1 mmol l–1)-stimulated increases in IP levels in cells expressing 5-HT2βPro (right). Values are means ± s.e.m., N=3, *P<0.05 vs 5-HT only. (B) Antagonist drugs have no significant effect on non-induced 5-HT1{alpha}Pro cells (left). None of these drugs (10 mmol l–1) blocks inhibition of adenylyl cyclase by 10–5 mol l–1 5-HT in cells induced to express 5-HT1{alpha}Pro (right). Some putative antagonists actually increase the efficacy of the 5-HT effect. Values are means ± s.e.m., N=3, *P<0.05 vs 5-HT only.





Right arrow Return to article