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About the Cover
Cover: The Drosophila heart is composed of inner spiral myofibers surrounded by longitudinal fibers. The sarcomeric units are visualized here by fusion of GFP to Cypher, a protein located at the Z-disc of sarcomeres (actin is stained by phalloidin in red). Mutations in various Z-disc components such as MLP (muscle LIM protein) cause cardiac dysfunction and cardiomyopathy. MLP deficiency in Drosophila leads to anomalies in heart rhythm and reduced lifespan (see article by Mery et al., pp. 15
−23), establishing Drosophila as a genetic model to study Z-disc protein-linked cardiomyopathy. Photograph by A. Mery.
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